ML228 - HIF Pathway Activator. CAS# 1357171-62-0 0161 Smiles: C/C(=N\NC(=S)N1CCC1)/C1=CC=CC=N1

Smiles: C/C(=N\NC(=S)N1CCC1)/C1=CC=CC=N1

Pinometostat

It increases the knock-in efficiency by two- to five-fold at different loci

Formula: C16H18N4O2

55368-40-6

ML228 - HIF Pathway Activator. CAS# 1357171-62-0 0161 Smiles: C/C(=N\NC(=S)N1CCC1)/C1=CC=CC=N1ML228, CAS No. 1357171 62 0, is a hypoxia inducible factor (HIF) pathway activator with an EC50 at ~1. 23 M in HRE gene reporter assay and ~1. 4 M in HIF 1 nuclear translocation assay. It does not inhibit the proteasome, but activates HIF stabilization and nuclear translocation, and induces expression of a HIF specific downstream gene (VEGF). It has no apparent toxicity below 30 M and appeared to be an iron chelator, independently of PHD. HIFs are